freya tirzepatide Check in! Completed my week 1 on GLP-1 , at 6 pounds down ! SW: 230 LBS Week 1: 224 LBS Link in my bio if you're interested in what I'm doing Here goes my Tirzepatide journey!

The science behind longer-term dosing interval for GLP-1 and NuSH peptides Achieving a monthly or longer-term dosing interval for GLP-1 peptide involves a number of factors and corresponding challenges below: 1) Longer half-life: Half-life is a measure of drug clearance rate which is essential to increasing dose interval

Rocca AS & Brubaker PL (2001)

By 2020, this had decreased to around 292,000

Saxenda is typically used at higher doses specifically for weight management, while Trulicity is primarily indicated for the treatment of type 2 diabetes, although it can also lead to weight loss as a side effect

Tirzepatide features a tyrosine at its Nterminus, which is typically required for high GIP receptor affinity but was also shown previously to attenuate GLP1 receptor arrestin recruitment efficacy as part of an exploration of exendin4 Nterminal substitutions (Jones, Bloom, et al., 2018)

Why Wegovy can cause headaches Most headaches on Wegovy come from indirect effects rather than the drug acting directly on the brain