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(5) Yu-Xiang Kong, Zhi-Shuai Li, Yuan-Bo Liu, Bo Pan, et al (2025) FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation Communications Biology, volume 8, Article number: 299 (2025)

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The endothelium also generates a variety of vasodilators and vasoconstrictors, including thromboxane A2, endothelin, and Ang II (80)

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In preclinical models of AD, this translates to significant therapeutic effects