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When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced
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Potential Benefits of Boosting NAD+ Laboratory studies and emerging clinical research suggest that increasing NAD+ levels may offer several potential benefits: Improved Energy Levels: By enhancing mitochondrial function, NAD+ can support more efficient energy production within cells
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