Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe pancreatitis, diabetic retinopathy requiring caution, and pregnancy or breastfeeding
While these medications are not absolutely contraindicated in these groups, the decision to prescribe should involve thorough discussion of individual circumstances, close monitoring, and consideration of alternative treatments
Chem Immunol (2000) 75:14668
2023 [cited 2025 Mar 6]
Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) Lancet