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Semaglutide, tirzepatide, and retatrutide represent three generations of incretin-based compounds

Indication-specific advantages: Glucagon co-agonists such as survodutide, mazdutide, and retatrutide may have superior hepatic effects in MASH and MASLD because glucagon acts directly on liver lipid metabolism

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It creates a feeling of fullness, leading to a natural reduction in caloric intake

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Although no formal contraindication exists for combining these interventions, the safety and efficacy of this combination have not been studied in clinical trials