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S.YullF
2007;105:c62-7
Journal of peptide science : an official publication of the European Peptide Society , 31 (6), e70016
It is noted that, whether in vitro or in vivo experiments, the combination of harmine and Ex-4 can significantly promote the proliferation of human -cells compared with harmine alone, which may also be related to the promotion of trans-differentiation from -cells to -cells [44]
The GLP-1 receptor agonists operate via several mechanisms that include increasing glucose-stimulated insulin secretion from the pancreatic beta cells, inhibiting the secretion of inappropriate glucagon in cases where blood glucose is high, slowing down gastric emptying to help control the glucose excursions, and activating brain centers such as the hypothalamus and brain stem to enhance satiety and suppress food intake
When selecting second-line therapy, clinicians might consider the comparative cardiovascular benefits of GLP-1RA
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