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Spectra were acquired using a stimulated echo acquisition mode (STEAM, [39]) pulse sequence (TE/TM = 11/32 ms, TR = 5 s, number of transients = 64) with variable power radiofrequency pulses with optimised relaxation delays (VAPOR, [40]) water suppression and outer volume saturation [41]

Most patients notice decreased appetite within 2448 hours, but measurable weight loss typically appears after 714 days as reduced calorie intake compounds

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