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Limitations include that although all GLP-1 agonist users had a record for obesity without diabetes, whether GLP-1 agonists were all used for weight loss is uncertain

In studies of people with type 2 diabetes, side effects were the number one reason for stopping treatment, which can feel discouraging if you are just starting out

People taking these medications require ongoing monthly refills to maintain weight loss

Patients with certain genetic profiles may experience more severe GI symptoms or differential weight loss patterns

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Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides