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Their well-known status as obesity and diabetes drugs also helps remove stigma around requesting them, and their design as a self-injectable medication allows easy at-home use

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Besides this, melatonin negatively modulates NF-B and COX-2 signaling, improving overall the therapeutic response [110, 111]

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Yet in April 2024, the smaller LIXIPARK trial had shown the opposite, with lixisenatide slowing motor decline in early Parkinsons disease over 12 months [3]