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1 Urinary frequency is often the first symptom of IC to arise, but patients may not recognize it as a problem until they have endured many years of it.5 Among patients with IC, 92% report urinary frequency: 86% say that they urinate more than 11 times during a 24-hour period and 71% say that they urinate 3 or more times at nightthe definition of nocturia

Conservative protocols involving cycling address this uncertainty by limiting continuous exposure

doi: 10.1016/S0006-3223(03)00465-7

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D.et al (2007)