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Western blot results revealed that, in si-NC cells, Erastin robustly downregulated the expression of tight junction proteins Claudin-1 and Occludin, as well as anti-ferroptotic markers GPX4 and SLC7A11 and these protein deficits were largely restored upon ATT-I co-treatment

In addition, both TTP and gAgAP downregulated transcription levels of angiotensin II receptor type 1 ( agtr1 ) and miR-132/-212, with TTP producing a comparable reduction in agtr1 to captopril and a significant decrease in miR-132/-212 expression

Han S, Zhao BS, Myers SA, Carr SA, He C, Ting AY

Spaek MJ, Poleszczuk J, Czarnecka AM, et al

In addition to activating the Akt signaling pathway, this drug facilitates apoptotic cell death, which is linked to increased phosphorylation of MEK and its downstream target ERK, decreased Bcl-2 levels, increased Bax expression, and greater activation of caspase-3 and caspase-9

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