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Vitamin C and Doxycycline: a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
10.1016/j.jff.2019.01.011 J Funct Foods
Further evidence for immediate secretion of GLP-1 from L-cells in the proximal gut comes from work by Schirra et al
Current treatments for HS include topical clindamycin, erythromycin, and gentamicin, oral antibiotics including tetracyclines, clindamycin, combined clindamycin and rifampicin, combined clindamycin and ofloxacin, biologics such as adalimumab, infliximab, secukinumab and off-label ustekinumab and brodalumab
These findings identify these metabolites as active components and suggest their potential as a therapeutic strategy to prevent early NAFLD by suppressing adipose tissue macrophage infiltration and systemic inflammation via JNK signaling (Figure 1A) (Wang et al., 2017)
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