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Ferroptosis, an iron-dependent non-apoptotic cell death driven by excessive lipid peroxidation, was first characterized by Dixon et al., in 2012 through studies on erastin and RAS-selective lethal compounds (Mahoney-Snchez et al., 2021

Semaglutide (brand names: Wegovy, Ozempic) is a drug developed to lower blood sugar levels and reduce the risk of major cardiovascular events such as heart attack or stroke in type two diabetes patients

Emerging research has also raised concerns about long-term melatonin use and cardiovascular health, including an observed association with a higher risk of heart failure

Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-gamma

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However, acid reflux is recognized as a potential adverse effect of semaglutide therapy