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Several cross-sectional and prospective cohort studies have reported that men with poorly controlled diabetes (as reflected by elevated Glycated Hemoglobin A1c (HbA1c) levels) exhibit significantly lower sperm concentration, reduced motility, and higher rates of sperm DNA fragmentation [10, 300]

In our previous study, we showed that the total antioxidant status and serum Cu concentration were significantly lower in women who had miscarriage in the first trimester of pregnancy, while Mn level was higher compared to women with a normal pregnancy

ER transcriptionally promotes the expression of SLC7A11 and SLC3A2 Given the observed association between ER and SLC7A11/SLC3A2 expression, we investigated how ER may regulate the expression SLC7A11 and SLC3A2

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