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The Phase 2 trial demonstrated that higher doses produce greater reductions in body weight, with the 12mg group achieving 24.2% average weight loss at 48 weeks

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Cait and colleagues note that activation of Podxl may assist with decreasing the permeability of the BBB in diseases such as multiple sclerosis or stroke, whereas increasing the permeability may help with temporarily opening the BBB to allow therapeutics to reach brain tissue

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Subacute combined degeneration of the spinal cord from folate deficiency

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