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Despite the overall efficacy of the incretin-based treatments for weight loss, there is a lack of long-term controlled studies beyond about 4 years available [221,222]

As always, interactions and risks are possible with any supplement, so speak to a naturopathic doctor or other regulated healthcare provider before starting any new supplements.

Monitor for insulin resistance and collaborating with the healthcare team to adjust insulin doses

Consider whether it correlates with a recent dose change

This can lead to reduced expression of GLP- 1 receptors and the development of GLP- 1 resistance

For example, we can observe how people who have suffered a heart attack have higher blood homocysteine levels (Ashjazadeh et al., 2013)