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Mol Pharmacol 61:989996 Chiechio S, Copani A, Nicoletti F, Gereau RW 4th (2006) l-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies

The conflicting data in some clinical studies may be explained by various factors: [1] most cohort studies lacked individual validation of fractures as primary outcomes, [2] the studies had short follow-up duration and [3] did not consider important risk factors for osteoporosis such as BMD (even though BMD is not a good method for diagnosing osteoporosis in T2DM), and [4] some studies included medications that affect fracture risk, such as corticosteroids or antidepressants

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