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This matters because it argues against simple collagen accumulation

Aedes albopictus (Skuse, 1894) is originally from Bengal, India and is indigenous to Southeast Asia [3]

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The appropriate response to that uncertainty is not to abandon the compound but to use it within a structured clinical framework: defined goals, evidence-appropriate dosing, quality-assured sources, systematic monitoring, and ongoing reassessment as the science matures

This is in stark contrast to their differential responses to the natural stimulus diacetyl (Fig 4B and C)