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The muscle-sparing data is still maturing, the question of how much of the dramatic weight loss is fat versus lean tissue is being answered in real time, and the answers will inevitably show patient-to-patient variability that the trial means cannot capture

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The peptide stimulates production of VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor), both critical for building new capillary networks

Managing insulin resistance can make weight loss feel more achievable, while spironolactone continues to manage skin and hair symptoms