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They release a cocktail of signaling molecules including TNF-alpha, interleukin-1, interleukin-6, bone morphogenetic proteins (BMPs), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta), and vascular endothelial growth factor (VEGF)

Rey NL, George S, Steiner JA et al (2018) Spread of aggregates after olfactory bulb injection of -synuclein fibrils is associated with early neuronal loss and is reduced long term

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This is the common administration method for studying musculoskeletal healing in animals [4]

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Imaging: For injuries, imaging can document structural changes over time