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Ultravioletvisible spectra were captured using a Lambda 465 (PerkinElmer) spectrometer

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A previous study investigated the expression of various genes correlated with cell death cascades and suggested that the expression of the proapoptotic protein Bax- was increased in the hippocampus of AD patients, whereas the expression of the antiapoptotic protein Bcl-2 was not altered

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Ferrini MG, Vernet D, Magee TR, Shahed A, Qian A, Rajfer J, et al

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 2% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof