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Both twins had several genetic variants associated with a higher risk of systemic inflammation

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Oral mucosal melanin hyperpigmentation associated with syndromes and systemic diseases Oral mucosal melanin hyperpigmentation is often observed in the systemic conditions such as Peutz-Jegher syndrome, McCune-Albright syndrome, Laugier-Hunziker syndrome, Addison disease, and neurofibromatosis

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doi: 10.1016/j.jdermsci.2009.08.003 39 Le PooleICvan den WijngaardRMWesterhofWVerkruisenRPDutrieuxRPDingemansKPet al

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