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The anti-adipogenic effect of PGF2 is mediated through prostaglandin F receptor-mediated elevation in intracellular calcium and DNA synthesis [168] and activation of MAPK, causing reduction in PPAR phosphorylation [169]

doi: 10.1039/d1fo02608a, PMID: [DOI] [PubMed] [Google Scholar] 41.Lv B, Wu Y, Lian J, Yu N, An T, Wang T, et al

High-affinity molecules can get trapped at the periphery of a tumor, never reaching the core

(2002) 283:E11351143

More frequent, slower dose increases allow for improved outcomes with lower risk of side effects

Furthermore, TMAO exacerbates VC through dose-dependent vascular smooth muscle cell calcification and activation of the NLRP3 inflammasome and NF-B signaling (Zhang et al., 2020), thereby further promoting thrombosis (Figure 6)