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We quantified microglial activation in the hippocampus and the whole brain of 10-week-old C57Bl/6J mice following inflammatory challenge, examining both the early (two days post-challenge

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Mechanistically, our analysis implicated a dysregulated sphingolipid pathway in the DCI brain, characterized by the upregulation of the transporter ATP-binding cassette transporter A2 (ABCA2) and the enzymes sphingosine-1-phosphate phosphatase 1 (SGPP1) and ceramide synthase 2 (CERS2)