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Cuproptosis, a recently discovered form of programmed cell death, is triggered by the accumulation of copper ions and involves the binding of copper to lipoylated proteins in the tricarboxylic acid (TCA) cycle, leading to protein aggregation and cellular demise [11,12,13]

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Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents

The GLOW stack combining all three uses these typical ratios

Additionally, PDHA1 knockdown significantly increased intracellular copper (II) levels (Supplementary Fig