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If you experience significant side effects at any dose, you can remain at that dose for 6-8 weeks before escalating, or temporarily step back to the previous dose

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Verma S, Poulter NR, Bhatt DL et al (2018) Effects of liraglutide on cardiovascular outcomes in patients with type 2 diabetes mellitus with or without history of myocardial infarction or stroke

The gap between 'works in rats' and 'safe and effective in humans' has ended promising compounds before