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Singly-housed rodents may have increased adiposity 101 and, moreover, singly-housed mice in standard caging can engage in coprophagy of their own feces that may impact their cecal microbiome 102

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That is, people with obesity have a higher risk of developing depression, and people with depression are also more likely to have excess weight

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Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR (2013) Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients