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Neither is sufficient alone, neither makes the other redundant

BMJ Open 8 , e023830 (2018)

Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

In addition, along with function recovery (Figure 11), BPC 157 counteracts muscle disability related to various noxious procedures, after abdominal aorta anastomosis (Hrelec et al., 2009), L2-L3 compression (Perovic et al., 2019), severe electrolytes disturbances (Baric et al., 2016

NICE recommends evidence-based weight management options including structured lifestyle interventions, orlistat, or semaglutide

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