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Glickman says

Yes, long-term use can cause permanent skin thinning, pigmentation, and sensitivity

Taken together, GCGR agonism offers a promising yet complex strategy in cardiometabolic disease, as it promotes weight loss and energy expenditure while also increasing blood glucose, underscoring the need for dual- and triple-agonist approaches (GLP1R/GIPR/GCGR) that balance metabolic and CV effects

doi:10.1024/0300-9831.79.3.131 Traina G

Unlike contamination (cloudiness, color change, precipitate), a calculation error produces clear solution that looks identical to correctly dosed solution

In Taiwans National Health Insurance program, the cost of a GLP-1RA (e.g., liraglutide) can be up to 7 times that of insulin (e.g., insulin glargine) per treatment cycle (e.g., US$108.6 versus US$15.4 per month) [6]