All bariatric surgeries are not created equal: insights from mechanistic comparisons
A detailed examination reveals more than 9 million prescriptions of Ozempic were issued in the fourth quarter of 2022 alone
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Has broadened the research interest in Semaglutide beyond its established metabolic applications and established it as one of the most pharmacologically significant and broadly relevant research compounds of the current era
Effects on hypothalamic neurons In studies in a mouse model (C57BL/6, ob/ob mice) after peripheral exposure to semaglutide, the following were observed: Activation of POMC/CART neurons in the arcuate nucleus (ARC) of the hypothalamus c-Fos mapping showed a 3-5-fold increase in immunoreactivity compared to control Inhibition of NPY/AgRP neurons reduction in NPY and AgRP mRNA expression measured by qPCR Activation of neurons in the nucleus of the solitary tract (NTS) in the brainstem an area integrating signals from the vagus nerve The effect of these neuronal changes was a statistically significant reduction in food consumption by animals (p 99% binding)
Insight: As Torrent Pharmaceuticals noted, to truly disrupt the entire market, GLP-1s must eventually bridge the massive price gap with existing oral gliptins, which currently cost just ~10 per tablet
