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81,107,109 Tanzeum was discontinued by GlaxoSmithKline (GSK) in 2017, primarily due to economic factors

Wadden TA et al

A molecule that fits perfectly into GLP-1 receptors might not activate GIP receptors effectively, and vice versa

After 4-6 weeks at the reduced dose, titrating back up may produce improved effects

However, as this was an observational target trial emulation conducted in a predominantly male Veterans Affairs population, the results support but do not establish causality and may have limited generalisability to broader populations, particularly women and non-veteran groups