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A growing body of research suggests that GLP-1 receptor agonists can improve several markers tied to cardiovascular risk, including blood pressure, cholesterol levels, blood sugar control, and inflammation

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Remember, this article was published in Nature Medicine, right

The trouble is, the modern world is no savannah

The anorectic effects of GLP-1 agonism are reported to result from the suppression of AgRP/NPY neurons and activation of POMC/CART neurons, and these responses occur upstream of MC4R [28, 29]