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In addition, peripheral inflammationlinked to comorbid conditions like diabetes and HIVmay exacerbate central neuroinflammatory responses (Isik et al., 2023

Cerebral Folate Deficiency and Autoimmune Mechanisms In some individuals, the immune system produces antibodies that block Folate Receptor Alpha (FRA)

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275,276 Therefore, AMPK can activate glycolysis, fatty acid oxidation and, also, NAD + metabolism

According to a study on LPS-induced ARDS, Nrf2 inhibits oxidative stress and attenuates ferroptosis via controlling the amounts of ferroptosis-related proteins, such as SLC7A11 and GPX4