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If you take levothyroxine and lose 20 or more pounds on tirzepatide, your thyroid medication dose may now be wrong

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The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]

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PMID: 102

The medication slows gastric emptying significantly, which can worsen conditions like gastroparesis, severe GERD, or inflammatory bowel disease