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A variety of GLP-1RAs and analogues, such as exendin-4 and liraglutide, has been used successfully in the treatment of type 2 diabetes mellitus (T2DM) (2)

Poor sleep disrupts several hormones involved in hunger and fullnessincluding GLP-1, leptin, ghrelin, cortisol, and insulin

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they exist only in clinical trials with varying investigational wearing durations

Most patients find that bowel changes are most noticeable during initial treatment and often improve as their body adapts to the medication, though some degree of altered bowel pattern may persist throughout treatment

In the new study, which has not yet been published in a peer-reviewed journal, researchers analyzed five years of medical records from more than 146,000 adults with a diagnosis of both obesity and Type 2 diabetes