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Recent evidence using several public datasets from The Cancer Genome Atlas (TCGA), Kyoyo Encyclopedia of Genes and Genomes (KEGG), AmiGO (2) and Reactome Pathways databases has identified two choline metabolism-related genes (choline kinase , CHKB , and phosphatidylethanolamine N-methyltransferase, PEMT ) as key genes involved in the pathogenesis of human colorectal cancer (220, 221)

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Specifically, the efficient execution of fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS)the core metabolic pathways fueling the M2 phenotypeis severely compromised in the diabetic milieu (Purvis et al., 2024

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