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Originally engineered at Washington State University by the Harding lab and later licensed to M3 Biotechnology, Dihexa retains the angiotensin IV pharmacophore for AT4 receptor binding while incorporating N-hexanoyl and aminohexanoic acid modifications that confer metabolic stability and lipophilic BBB penetration

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density

He added that the drugs effects on the brains emotion and reward pathways also suggest that they may be repurposed to treat other conditions besides obesity, such as substance use disorders

Journal of Biological Chemistry 279 (46): 4753647542