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Its evidence base is older, limited, and genuinely conflicting, with no robust modern human trials establishing efficacy for sleep or any other use

Angewandte Chemie International Edition, 2014

Most patients report feeling significantly better within 30 to 60 minutes, since IV delivery bypasses the digestive system that may already be irritated

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Multiple studies demonstrate that womens pain reports are more likely to be attributed to psychological or emotional factors compared to mens reports (Samulowitz et al., 2018)