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For patients with BMIs that started above 35, significant metabolic syndrome, or a history of yo-yo dieting, maintenance dosing often produces the best long-term outcomes

It is important not to significantly restrict fluid or food intake beyond what the medication naturally induces, as this can lead to nutritional deficiencies or dehydration

However, weight loss itself can affect hormones (PCOS symptoms often improve with fat loss, for example), and individual responses vary

Exendin-4 induces bone marrow stromal cells migration through bone marrow-derived macrophages polarization via PKA-STAT3 signaling pathway

Based on these patterns, both body weight and indicators linked to diabetes and heart disease were expected to return to levels seen before treatment within less than two years

Any suspected side effects should be reported to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk or via the Yellow Card app