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But when supplement companies claim their products boost GLP-1 levels or support GLP-1 activity, what does that actually mean

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However, most clinical trials enrolled participants with obesity, so evidence is strongest in that population

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In particular, the phosphoinositide-3 kinase (PI3K-PKB)/Akt pathway and the Ras/mitogen-activated kinase (MAPK) are involved [54, 57], thus affecting cell survival, energy metabolism, synaptic plasticity, and memory and learning processes

The tricky part is that early warning signs can look a lot like typical GLP-1 side effects, so it's easy to write off symptoms that actually deserve attention