Compared to M2-type macrophages, M1-type macrophages exhibit elevated expression of hepcidin antimicrobial peptide (Hamp), ferritin heavy chain (FTH), and ferritin light chain (FTL), with reduced levels of FPN and iron regulatory proteins 1/2 (IRP1/2), demonstrating enhanced iron storage capacity (96)
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This study also demonstrated the role of ferroptosis in obstructive nephropathy
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Systemic inflammation can disrupt the blood-brain barrier and elevate the levels of proinflammatory cytokines, contributing to oxidative stress and impacting neurotransmitters associated with ADHD [151]
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