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The peptide works best as part of a comprehensive approach including proper nutrition, regular exercise, and lifestyle optimization rather than as a standalone intervention

Cardiovascular outcomes, long-term efficacy and safety In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits [109]

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NNMT Expression in Metabolic Disease

The 3.48% reduction in apoptotic cells did not reach statistical significance, though the molecular markers (caspase-3, PARP, Bcl-2/Bax) were all significant