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ber den Proteinkinase-A-Signalweg werden Kaliumkanle geschlossen, die resultierende Depolarisation der Zellmembran fhrt zur ffnung spannungsabhngiger Calciumkanle

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In the definitive SURMOUNT-5 head-to-head trial (NEJM 2025), tirzepatide produced ~20% weight loss vs

IMC also prevented diet-driven hepatic cholesterol accumulation and caused both upregulation of the host hepatic bile acid synthetic enzyme CYP7A1 and altered the expression of hepatic genes critical for bile acid feedback regulation