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After menopause, estrogen production occurs not from the ovaries but at peripheral adipose tissue sites, where estrone is produced [10, 21, 22]

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7.1 Identification of gutliver axisrelated therapeutic targets The future studies to systematically identify key molecular targets involved in gutliver communication during cadmium exposure, including intestinal barrier regulators, bile acid signaling pathways, microbial metabolites, and inflammatory mediators, which may serve as potential intervention targets