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Schiavoni, I

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This growing clinical challenge highlights the urgent need for structured strategies, including risk stratification, tailored dose titration, and multidisciplinary care, to balance metabolic efficacy with gastrointestinal tolerability

Combined with a low-fat diet, 5-Amino-1MQ treatment rapidly normalized body weight and adiposity to levels matching age-matched lean animals, an outcome that diet alone could not achieve in the same timeframe

TRIUMPH-5 is a comparator study in type 2 diabetes, benchmarking retatrutide against an active comparator rather than placebo