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Many studies found beneficial effects of NAC in COPD patients (reviewed in [98]), although the efficacy of NAC in reducing disease severity was ascribed to NACs mucolytic activity rather than its function as GSH precursor [97]

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Readers researching the broader hepatocyte growth factor / c-Met pathway for cognitive indications should be aware that Fosgonimeton (development code ATH-1017), a structurally distinct small-molecule prodrug developed by Athira Pharma as an HGF positive modulator, has been investigated in three clinical trials in dementia indications

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