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The reported Km of glutathione reductase for GSSG is 65 mol /L and for NADPH 8.5 mol /L Erythrocyte lysates were incubated with a saturating concentration of GSSG (1 mmol /L) and either NADPH or NADH (100 mol /L)

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Landis MN, Arya M, Smith S, Draelos Z, Usdan L, Tarabar S, et al

The non-toxic metabolites are then excreted out of the body, and no harm, no foul

This might result in increased body mass