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Morgan Stanley Research has forecast that China and Brazil could see rapid expansion in GLP-1 uptake as generic competition reduces prices substantially

Potential concerns include appetite stimulation, which may counteract weight-loss goals, and ghrelin-mediated effects on cortisol and sleep

Finally, other broader options have involved reduction of presumed glutamatergic excitotoxicity (minocycline, acamprosate, lamotrigine)

Even then, systemic bioavailability rarely exceeds single-digit percentages for most compounds

This piece was inspired by our recent interview with Theresa Yee, a London-based trend forecaster and journalist specializing in beauty and wellness