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Overexpression of MRP1, which represents the strength of cancer cells, can be targeted by substances such as verapamil, which specifically target this transporter and trigger lethal oxidative stress in the cancer cell

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Besides, berberine can prevent NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome from being activated during the inflammation process of Parkinsons disease and restore autophagy activity to protect dopamine neurons ( In addition to the above studies, in the zebrafish Parkinsons disease model, berberine derivatives can be used to treat Parkinsons disease

Aging Cell 16 , 918933 (2017)

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis