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Differential diagnosis: Cholangiofibrosismarked pericholangial fibrosis with proliferation of biliary epithelium and metaplastic changes of glandular epithelium (e.g., goblet cells, Paneth cells)

Each receptor contributes differently to the overall effect, and each activates at different dose thresholds

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Thus, it is tempting to attribute an increase in lactate to an imbalance between glycolysis and mitochondrial oxidation, similar to, but less severe than hypoxia